The Claim
Among adults with type 2 diabetes, low serum folate is associated with increased cardiovascular disease mortality through partial mediation by elevated homocysteine levels, while high serum vitamin B12 is associated with cardiovascular disease mortality independently of homocysteine levels.
What the research says
Not yet evaluated
We are still looking at what the research says.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In people with type 2 diabetes, low folate might raise the risk of dying from heart disease because it leads to higher homocysteine, but high vitamin B12 affects heart disease risk on its own, no matter what homocysteine levels are.
See the scientific wording
Among adults with type 2 diabetes, the association between low serum folate and cardiovascular disease mortality is partially mediated by elevated homocysteine levels, while the association between high serum vitamin B12 and mortality is independent of homocysteine.
Score breakdown, mechanism chain, raw evidence, ideal studies needed
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.