Analysis Version
v1
History
Back to Study: Associations of Serum Folate and Vitamin B12 Level...
mechanistic
Analysis v1

In people with type 2 diabetes, low folate might raise the risk of dying from heart disease because it leads to higher homocysteine, but high vitamin B12 affects heart disease risk on its own, no matter what homocysteine levels are.

Evidence from Studies

Supporting (0)

0

Community contributions welcome

No supporting evidence found

Contradicting (1)

0

Community contributions welcome

59

Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes

Cohort Study
Human
2022 Jan 4

The study looked at folate and B12 levels and death from heart disease in diabetics, but it didn’t measure homocysteine at all — so we can’t tell if homocysteine is the reason behind the links, as the claim says.

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes

Score: 59
DOI: 10.1001/jamanetworkopen.2021.46124

Similar Assertions

For people with type 2 diabetes, having higher levels of folate (a B vitamin) in their blood doesn’t seem to make them more likely to die from heart disease, compared to people with moderate folate levels.

59
0
83%

People with type 2 diabetes who have low levels of folate (a B vitamin) in their blood are 43% more likely to die from heart disease than those with moderate folate levels—so low folate might be linked to worse heart outcomes.

59
0
82%

For people with type 2 diabetes, having too little or too much vitamin B12 in the blood might increase the chance of dying from heart disease — the safest range seems to be in the middle.

59
0
72%

In people with type 2 diabetes, having very high levels of vitamin B12 in the blood seems to be linked to a much higher chance of dying from heart disease—higher than at any other B12 level—so maybe high B12 isn’t helping, but instead signals something else wrong in the body.

59
0
71%