In pregnant women who don’t have diabetes, things like red blood cell size and volume don’t seem to affect their HbA1c blood test results in any meaningful way.

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Pro

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Against

Evidence from Studies

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Contradicting (1)

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Glycated hemoglobin and red blood cell indices in non-diabetic pregnant women

Cross-Sectional Study

Human

2017 Sep 15

The study looked at blood markers in pregnant women without diabetes and found that HbA1c was linked to one of the red blood cell measures (MCHC), which goes against the claim that none of these measures affect HbA1c.

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Source Study

Glycated hemoglobin and red blood cell indices in non-diabetic pregnant women

Score: 37

DOI: 10.4081/cp.2017.999

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In pregnant women without diabetes, having more red blood cells might make their blood sugar test results look higher than they really are, even if their actual sugar levels are normal.

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In pregnant women who don’t have diabetes, blood traits like hemoglobin and hematocrit can slightly predict their average blood sugar levels — but other traits like MCHC and PDW don’t hold up when we adjust for other factors.

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In pregnant women who don’t have diabetes, having denser hemoglobin in their red blood cells might be linked to slightly higher blood sugar levels over time.

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In pregnant women without diabetes, having more hemoglobin in the blood is linked to slightly higher HbA1c levels — a marker usually tied to blood sugar — suggesting that blood cell levels might affect this test even if sugar isn't high.

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