The Claim
In the isolated-perfused rat liver, L-triiodothyronine (T3) increases the uptake of alanine and 14C-α-amino-isobutyric acid without altering cAMP levels, protein kinase activity, or Embden-Meyerhof pathway intermediates, indicating that T3 stimulates gluconeogenesis through a cAMP-independent pathway.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In rat livers removed from the body and maintained in a controlled system, the hormone T3 increases the uptake of two specific amino acids used to make glucose, without changing levels of cAMP, protein kinase activity, or glycolytic intermediates, demonstrating that this effect occurs through a pathway not involving cAMP.
See the scientific wording
In the isolated-perfused rat liver, L-triiodothyronine (T3) increases alanine and 14C-α-amino-isobutyric acid uptake without altering cAMP levels, protein kinase activity, or Embden-Meyerhof pathway intermediates, indicating a cAMP-independent pathway for gluconeogenic stimulation.
The thyroid hormone T3 enters liver cells and triggers a rapid increase in the uptake of amino acids like alanine, which are used to build glucose. At the same time, T3 boosts energy production in the mitochondria, and this energy is moved into the main part of the cell to power the glucose-making process. This happens without using the cAMP signaling system or changing glycolysis.
What the research says
1 studyIn rat livers kept alive in a lab setup, the thyroid hormone T3 helps the liver grab more amino acids to make glucose, but it doesn’t use the usual cAMP signal to do it — it finds another way, which matches what the claim says.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.