The Claim
In the isolated-perfused rat liver, L-triiodothyronine (T3) rapidly increases hepatic glucose production by enhancing amino acid uptake and mitochondrial ATP regeneration, independent of cAMP signaling.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In isolated rat livers, the hormone T3 directly increases glucose production by boosting the uptake of amino acids and restoring mitochondrial energy supply, without involving cAMP signaling.
See the scientific wording
In the isolated-perfused rat liver, L-triiodothyronine (T3) rapidly increases hepatic glucose production by enhancing amino acid uptake and mitochondrial ATP regeneration, independent of cAMP signaling, demonstrating a direct biochemical mechanism for gluconeogenic stimulation under controlled experimental conditions.
T3 hormone enters liver cells and triggers a fast energy boost by pulling in more amino acids and increasing ATP production in the mitochondria. This ATP moves to the cell's main compartment to power the conversion of amino acids into glucose, without using any cAMP signals.
What the research says
1 studyIn a rat liver kept alive outside the body, scientists gave it T3 hormone and saw it make more sugar by pulling in more amino acids and boosting its energy supply—without using the usual cAMP signal. So yes, T3 directly helps the liver make sugar in this setup.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.