In rats, a drug called propylthiouracil changes how the liver processes thyroid hormones, leading to more sulfate-bound thyroxine being released into bile and a sharp drop in the ratio of two...

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Effects of propylthiouracil on the biliary clearance of thyroxine (T4) in rats: decreased excretion of 3,5,3'-triiodothyronine glucuronide and increased excretion of 3,3',5'-triiodothyronine glucuronide and T4 sulfate.

Cohort Study

Animal

1989 Oct

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No contradicting evidence found

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Source Study

Effects of propylthiouracil on the biliary clearance of thyroxine (T4) in rats: decreased excretion of 3,5,3'-triiodothyronine glucuronide and increased excretion of 3,3',5'-triiodothyronine glucuronide and T4 sulfate.

Score: 12

DOI: 10.1210/ENDO-125-4-2175