In rats, eating a lot of fructose (like table sugar) led to higher levels of insulin, triglycerides, and uric acid compared to eating dextrose (a different sugar), suggesting fructose might have unique effects on metabolism. This finding is from the abstract summary - full study details were not available

In lab rats, eating a diet super high in fructose (like from sugary foods) makes their blood fat levels skyrocket—way more than other unhealthy diets—and this seems to mess up how their body handles fat overall, not just hurt the liver.

When male rats eat a lot of sugar, their bodies have a harder time managing blood sugar and fats, just like when they eat a lot of fat — so both kinds of diets might mess up their metabolism in similar ways.

In male rats, eating a lot of sugar (fructose) causes health problems like trouble processing insulin and cell stress, just like eating a lot of fat does—so sugar might be just as bad for your metabolism as fat.

Eating too much fructose over a long time can mess up how your liver responds to insulin, making your body produce more insulin, cause body-wide inflammation, and raise fat levels in your blood—all of which raise your risk of heart disease.

In rats eating a high-fructose diet, drugs that lower uric acid (allopurinol or benzbromarone) were linked to lower levels of insulin, blood pressure, triglycerides, and weight compared to rats not receiving these drugs. This finding is from the abstract summary - full study details were not available