Fructose, uric acid, and health problems in rats
A causal role for uric acid in fructose-induced metabolic syndrome.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Uric acid causes metabolic syndrome, not just a symptom
Previously, high uric acid was thought to be a side effect of metabolic syndrome, but this study suggests it's a root cause
Practical Takeaways
Reduce intake of high-fructose foods like sugary drinks and processed snacks
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Uric acid causes metabolic syndrome, not just a symptom
Previously, high uric acid was thought to be a side effect of metabolic syndrome, but this study suggests it's a root cause
Practical Takeaways
Reduce intake of high-fructose foods like sugary drinks and processed snacks
Publication
Journal
American journal of physiology. Renal physiology
Year
2006
Authors
T. Nakagawa, Hanbo Hu, Sergey I Zharikov, Katherine R. Tuttle, R. Short, Olena Y. Glushakova, Xiaosen Ouyang, D. Feig, E. Block, J. Herrera-Acosta, J. Patel, Richard J. Johnson
Related Content
Claims (6)
Fructose metabolism in the liver produces uric acid, which impairs endothelial function by reducing nitric oxide availability and arterial relaxation.
In rats, eating a lot of fructose (like table sugar) led to higher levels of insulin, triglycerides, and uric acid compared to eating dextrose (a different sugar), suggesting fructose might have unique effects on metabolism. This finding is from the abstract summary - full study details were not available
In rats eating a high-fructose diet, drugs that lower uric acid (allopurinol or benzbromarone) were linked to lower levels of insulin, blood pressure, triglycerides, and weight compared to rats not receiving these drugs. This finding is from the abstract summary - full study details were not available
Higher levels of uric acid made blood vessels less able to widen in response to a chemical signal, which could affect blood flow. This finding is from the abstract summary - full study details were not available
Eating fructose (like table sugar) led to higher uric acid levels in rats compared to other sugars. This finding is from the abstract summary - full study details were not available