Fructose (a type of sugar) creates uric acid, which stops blood vessels from relaxing properly by reducing nitric oxide.
Scientific Claim
Fructose metabolism in the liver produces uric acid, which impairs endothelial function by reducing nitric oxide availability and arterial relaxation.
Original Statement
“The third pathway involves fructose which is metabolized almost entirely in the liver. When fructose is broken down it generates uric acid as a byproduct. Elevated uric acid has been shown in multiple studies to impair endothelial function meaning it reduces nitric oxide availability and prevents arteries from relaxing properly.”
Context Details
Domain
cardiology
Population
human
Subject
fructose metabolism
Action
produces
Target
uric acid impairing endothelial function
Intervention Details
Evidence from Studies
Supporting (2)
A causal role for uric acid in fructose-induced metabolic syndrome.
This study found that high levels of uric acid, which can be caused by eating too much fructose, can lead to metabolic problems and impaired blood vessel function.
This study found that high levels of uric acid can reduce the production of a chemical that helps blood vessels relax, which can lead to blood vessel problems.
Contradicting (2)
This study found that uric acid levels may not be as important for blood vessel function as previously thought in healthy people.
This study found that a certain antioxidant can help reduce uric acid levels in rats fed a high-sugar diet.