Eating fructose (like table sugar) led to higher uric acid levels in rats compared to other sugars. This finding is from the abstract summary - full study details were not available

In rats eating a high-fructose diet, drugs that lower uric acid (allopurinol or benzbromarone) were linked to lower levels of insulin, blood pressure, triglycerides, and weight compared to rats not receiving these drugs. This finding is from the abstract summary - full study details were not available

Fructose metabolism in the liver produces uric acid, which impairs endothelial function by reducing nitric oxide availability and arterial relaxation.