When people stopped taking semaglutide, their brain started signaling hunger more strongly and fullness less strongly, making them feel hungrier again.

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Pro

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Evidence from Studies

Supporting (1)

26

Community contributions welcome

26

Post-semaglutide weight regain in females with obesity: Associations with gut microbiota, bile acid metabolism, and central nervous system.

Cohort Study

Human

2026 Feb 18

After people stopped taking semaglutide, their brains started signaling hunger more and fullness less — and the study found the exact same thing happened in rats, proving the drug’s effect on appetite control reverses when you stop taking it.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Post-semaglutide weight regain in females with obesity: Associations with gut microbiota, bile acid metabolism, and central nervous system.

Score: 26

DOI: 10.1111/dom.70571

Similar Assertions

When people stop taking semaglutide, they often gain weight back and feel hungrier — and this might be because their gut bacteria and metabolism go back to how they were before, which could be telling their brain to eat more.

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