In rats, the ratio of two specific thyroid hormone metabolites in bile drops sharply after propylthiouracil treatment, making it a reliable marker for detecting inhibition of the enzyme that breaks...

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Effects of propylthiouracil on the biliary clearance of thyroxine (T4) in rats: decreased excretion of 3,5,3'-triiodothyronine glucuronide and increased excretion of 3,3',5'-triiodothyronine glucuronide and T4 sulfate.

Cohort Study

Animal

1989 Oct

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Effects of propylthiouracil on the biliary clearance of thyroxine (T4) in rats: decreased excretion of 3,5,3'-triiodothyronine glucuronide and increased excretion of 3,3',5'-triiodothyronine glucuronide and T4 sulfate.

Score: 12

DOI: 10.1210/ENDO-125-4-2175