In rats with a form of PCOS induced by testosterone and insulin resistance, a diet lower in carbohydrates and higher in protein for 20 days was linked to lower levels of two inflammatory markers,...
Mechanism
Synthesis from 1 study
Eating fewer carbs and more protein lowers sugar levels in the body, which means fewer harmful molecules form and trigger inflammation. This leads to less of a key inflammatory signal being produced, reducing overall inflammation.
Most probable mechanism
Eating fewer carbs and more protein means less sugar in the body, which leads to fewer harmful molecules called AGEs forming. Fewer AGEs mean less activation of a receptor that triggers inflammation, which in turn lowers the production of a key inflammatory signal called IL-6.
Reduced dietary carbohydrate intake decreases the availability of reducing sugars that react non-enzymatically with proteins and lipids to form advanced glycation end products (AGEs)
Lower circulating AGE levels reduce binding to the receptor for advanced glycation end products (RAGE) on macrophages and adipocytes
Reduced RAGE activation decreases stimulation of the NF-κB signaling pathway in immune and metabolic cells
Suppressed NF-κB signaling reduces transcription and secretion of interleukin-6 from macrophages and adipose tissue
Less supported by current evidence, but not ruled out
Eating less of foods cooked at high temperatures reduces the amount of harmful AGEs swallowed from food, which lowers the total amount of these molecules in the body.
Reduced consumption of high-temperature cooked carbohydrates lowers exogenous intake of pre-formed advanced glycation end products (AGEs)
Lower exogenous AGE intake contributes to reduced total systemic AGE burden
Evidence from Studies
Supporting (1)
Community contributions welcome
Contradicting (0)
Community contributions welcome
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.