In rats with a condition mimicking PCOS and insulin resistance, a diet lower in carbohydrates and higher in protein for 20 days lowered levels of the inflammatory marker interleukin-6 compared to a...
Mechanism
Synthesis from 1 study
This diet lowers sugar intake, which means fewer harmful molecules form in the body. Those molecules normally trigger inflammation, so when they drop, less of the inflammatory signal IL-6 is made and released into the blood.
Most probable mechanism
Eating fewer carbs and more protein in these rats means less sugar in their food, which leads to fewer harmful molecules called AGEs forming in their bodies. Fewer AGEs mean less activation of a receptor called RAGE on immune and fat cells, which in turn turns down a chemical signal (NF-κB) that tells cells to make inflammation-causing substances like IL-6. As a result, less IL-6 gets released into the blood.
Reduced dietary carbohydrate intake decreases the availability of reducing sugars that drive non-enzymatic glycation reactions with proteins and lipids
Lower glycation activity reduces circulating levels of advanced glycation end products (AGEs)
Decreased AGE concentration reduces binding to the receptor RAGE on macrophages and adipocytes
Reduced RAGE activation suppresses downstream stimulation of the NF-κB signaling pathway
Suppressed NF-κB activity decreases transcription and secretion of interleukin-6 from immune and adipose cells
Evidence from Studies
Supporting (1)
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