In rats with a form of polycystic ovary syndrome induced by testosterone and insulin resistance, a diet lower in carbohydrates and higher in protein for 20 days lowered levels of Advanced Glycation...
Mechanism
Synthesis from 1 study
Eating fewer carbs means less sugar in the blood, so fewer harmful molecules called AGEs form by accident. This directly lowers the levels of these molecules in the blood. Less AGEs also means less activation of inflammation pathways, but that part is less directly proven.
Most probable mechanism
Eating fewer carbs means less sugar in the blood, which means sugar molecules have fewer chances to stick to proteins and fats by accident. This accident creates harmful molecules called AGEs. With fewer AGEs, there’s less damage and inflammation in the body.
Dietary carbohydrate intake is reduced, lowering the availability of reducing sugars such as glucose and fructose in circulation
Reduced circulating reducing sugars decrease non-enzymatic glycation reactions between sugars and proteins or lipids
Lower formation of advanced glycation end products (AGEs) reduces their accumulation in serum
Less supported by current evidence, but not ruled out
Fewer AGEs mean they bind less to a receptor called RAGE on immune cells, which stops a chain reaction that would otherwise turn on inflammation genes and release more inflammatory signals.
Lower serum AGE levels reduce binding to the receptor for advanced glycation end products (RAGE) on macrophages and adipocytes
Reduced RAGE activation decreases stimulation of the NF-κB intracellular signaling pathway
Suppressed NF-κB signaling reduces transcription and secretion of pro-inflammatory cytokines such as IL-6
Evidence from Studies
Supporting (1)
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