The Claim

In adults with severe burn injuries covering 25–50% of total body surface area, daily administration of oxandrolone at 20 mg/day for 7–10 days post-injury reduces net weight loss and nitrogen loss to levels comparable to those achieved with human growth hormone, maintains metabolic rate near baseline, and does not cause hyperglycemia in half of the patients.

Source: Comparison of the anabolic effects and complications of human growth hormone and the testosterone analog, oxandrolone, after severe burn injury.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
55score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

In adults with severe burns covering 25–50% of their body, taking 20 mg of oxandrolone daily for 7–10 days after injury reduces weight and nitrogen loss to the same level as human growth hormone, keeps metabolic rate close to normal, and does not raise blood sugar in half of the patients.

See the scientific wording

In adults with severe burn injuries covering at least 25–50% of total body surface area, daily oxandrolone at 20 mg/day for 7–10 days post-injury reduces net weight loss and nitrogen loss to levels comparable to human growth hormone, while maintaining metabolic rate near baseline and without reported hyperglycemia in half the patients.

Why this might work

Oxandrolone enters muscle and liver cells and binds to androgen receptors, which turn on genes that build proteins and turn off genes that break down muscle. This keeps body weight and nitrogen from dropping, repairs skin faster, and does not raise blood sugar or increase metabolism because it does not interfere with insulin signaling.

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: Comparison of the anabolic effects and complications of human growth hormone and the testosterone analog, oxandrolone, after severe burn injury.

    In severely burned adults, taking oxandrolone every day helps keep muscle and body weight from falling, just as well as HGH, but without causing high blood sugar or speeding up metabolism like HGH often does.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.