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Strong Support

In people with chronic fatigue syndrome who have specific autoantibodies, selenium in the blood does not correlate with the activity of an enzyme called glutathione peroxidase 3, suggesting that selenium is not reaching the kidneys properly even though overall selenium levels in the body are normal.

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Evidence from Studies

Supporting (1)

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Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone

Case-Control Study
Human
2023 Sep

In some people with chronic fatigue syndrome, their immune system makes antibodies that block selenium from reaching the kidneys, so even if selenium levels in the blood look normal, the kidneys can’t use it properly to make important enzymes.

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No contradicting evidence found

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Source Study

Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone

Score: 54
DOI: 10.1016/j.redox.2023.102796

Similar Assertions

A specific type of antibody that targets selenoprotein P is found in a higher percentage of people with chronic fatigue syndrome than in people without the condition.

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78%

People with chronic fatigue syndrome who have autoantibodies targeting selenoprotein P show lower levels of markers indicating thyroid hormone conversion to its active form, compared to those without these autoantibodies.

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72%

People with chronic fatigue syndrome who have specific antibodies targeting selenoprotein P excrete less iodine in their urine than those without these antibodies or healthy individuals, suggesting a reduction in the release of iodide from thyroid hormones caused by decreased deiodinase enzyme function.

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70%