The Claim
The MCM6 intron 13 region, containing the C/T-13910 SNP, displays genotype-dependent DNA methylation patterns that increase with age in lactase non-persistent individuals (CC genotype) and decrease or remain stable in lactase persistent individuals (TT genotype), with these methylation patterns correlating with 29-fold differences in lactase mRNA levels across adults.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
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In adults, the level of DNA methylation at a specific genetic region near the lactase gene changes with age differently depending on whether a person can or cannot digest lactose, and these changes are linked to a 29-fold difference in lactase gene activity.
See the scientific wording
The MCM6 intron 13 region, which contains the C/T-13910 SNP, exhibits genotype-dependent DNA methylation patterns that increase with age in lactase non-persistent individuals (CC genotype) and decrease or remain stable in lactase persistent individuals (TT genotype), correlating with 29-fold differences in lactase mRNA levels across adults.
In people with two C copies of a gene variant near the lactase gene, methylation builds up over time on DNA regions that turn on lactase production, blocking the signals that keep the gene active. This turns off lactase production as they age. In people with two T copies, the same DNA regions stay unmethylated, allowing the gene to stay active and keep producing lactase throughout life.
What the research says
1 studyStudy: Lactase non-persistence is directed by DNA variation-dependent epigenetic aging
People with two C copies of a gene near the lactase gene become more methylated as they age, which turns down milk-digesting enzyme production, while those with two T copies stay unmethylated and keep making the enzyme — explaining why some adults can digest milk and others can't.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.