In male Nothobranchius furzeri fish with genetic diversity, reducing food intake by feeding less often and in smaller portions does not increase lifespan, unlike in genetically uniform fish where...
Mechanism
Synthesis from 1 study
When food comes only every other day, the body switches on repair systems that slow aging. When food is given every day but less of it, those repair systems stay off. Outbred fish do not respond to daily少吃 the same way inbred fish do because their genes make them less sensitive to this pattern.
Most probable mechanism
When food is given less often, the body detects periods without food and turns on specific survival pathways that protect cells. When food is given daily but in smaller amounts, those same pathways stay off, so the body does not activate protection, and aging continues at the same rate.
Intermittent fasting triggers sustained low glucose and insulin levels during fasting intervals, activating AMPK and sirtuin pathways that enhance cellular repair and reduce oxidative damage
Daily caloric restriction maintains near-constant nutrient availability, preventing sustained activation of AMPK and sirtuin pathways and failing to suppress mTOR-driven anabolic signaling
Failure to suppress mTOR signaling under daily restriction permits continued protein synthesis and accumulation of damaged cellular components, accelerating aging processes
Genetic diversity in outbred populations alters the sensitivity of nutrient-sensing pathways to nutrient fluctuations, reducing the effectiveness of daily restriction compared to intermittent fasting
Evidence from Studies
Supporting (1)
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Neither caloric nor protein restriction increases the male lifespan of outbred short-lived fish
Contradicting (0)
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