In rats with a lab-induced form of PCOS, blood levels of Advanced Glycation End Products (AGEs) were similar to those in healthy rats, indicating that the PCOS induction method did not increase AGEs...
Mechanism
Synthesis from 1 study
Giving rats testosterone to make them have PCOS doesn't make more sugar stick to their proteins in the blood, because their diet and blood sugar levels stay the same as in healthy rats. So, no extra AGEs build up unless they eat more sugary foods.
Most probable mechanism
In these rats, making them have PCOS by giving them testosterone doesn't cause more sugar molecules to stick to proteins in the blood, because the amount of sugar in their blood and diet stays about the same as in healthy rats, so no extra AGEs are made.
Testosterone-induced PCOS does not alter circulating levels of reducing sugars such as glucose and fructose in rats on a standard diet
Normal dietary intake of carbohydrates in the standard diet provides consistent substrate availability for non-enzymatic glycation reactions
No increase in endogenous AGE formation occurs because glycation reactions remain at baseline rates due to stable precursor levels
Evidence from Studies
Supporting (1)
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