The Claim
A 10-day supplementation with L-citrulline at 100 mg/kg/day was associated with a trend toward increased time to exhaustion in female participants, though the change was not statistically significant.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In a study of female participants, taking L-citrulline for 10 days at a dose of 100 mg per kilogram of body weight showed a slight increase in how long they could exercise before becoming exhausted, but the change was not large enough to be considered statistically reliable.
See the scientific wording
A trend toward improved time to exhaustion was observed in female participants following 10-day L-citrulline supplementation at 100 mg/kg/day, but this finding was not statistically significant and may reflect a subgroup effect requiring further investigation.
L-citrulline is converted into arginine in the kidneys, which increases the amount of arginine available for making nitric oxide in blood vessel walls. Nitric oxide relaxes the smooth muscle in blood vessels, allowing more blood to flow to working muscles. This increased blood flow delivers more oxygen, which helps delay the point at which muscles become too fatigued to continue working.
What the research says
1 studyWomen who took L-citrulline rode longer on a bike test than when they took a placebo, but the difference wasn’t big enough to say for sure it wasn’t just luck — and the study says we need to look into this more.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.