The Claim

In resistance-trained males, the increase in lean mass following 4 weeks of supplementation with glutathione and L-citrulline is positively correlated with gains in muscle strength, but no such correlation is observed in groups receiving placebo or L-citrulline-malate.

Source: Eight weeks of resistance training in conjunction with glutathione and L-Citrulline supplementation increases lean mass and has no adverse effects on blood clinical safety markers in resistance-trained males

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
63score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

In men who train with weights, those who take glutathione and L-citrulline for four weeks show a consistent relationship between gains in lean mass and gains in muscle strength, but this relationship does not occur in those who take a placebo or L-citrulline-malate.

See the scientific wording

In resistance-trained males, the increase in lean mass following 4 weeks of supplementation with glutathione and L-citrulline is positively correlated with gains in muscle strength, but this correlation is not observed in placebo or L-citrulline-malate groups.

Why this might work

Glutathione and L-citrulline together increase nitric oxide in the muscle, which triggers a chain reaction that boosts protein building and improves how well nerves activate muscle fibers, causing muscle growth and strength to rise together.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: Eight weeks of resistance training in conjunction with glutathione and L-Citrulline supplementation increases lean mass and has no adverse effects on blood clinical safety markers in resistance-trained males

    In trained men, those who took glutathione and L-citrulline together not only gained more muscle but also got stronger — and these two changes went hand in hand. But if they took just L-citrulline-malate or a placebo, gaining muscle didn’t mean they got stronger.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.