In tumors that produce excess TSH hormone, the proteins that respond to thyroid hormones are not detectable, even though the genetic instructions to make them are present. This suggests a problem in converting those instructions into functional proteins, which could disrupt the body's normal control of TSH levels.

27

Pro

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Against

Evidence from Studies

Supporting (1)

27

Community contributions welcome

27

An Abnormality of Thyroid Hormone Receptor Expression May Explain Abnormal Thyrotropin Production in Thyrotropin-Secreting Pituitary Tumors

Case-Control Study

Human

1998 Jan

In people with this rare tumor, the body makes the instructions (mRNA) to build thyroid hormone sensors, but the sensors themselves (proteins) don’t get made. Without these sensors, the brain can’t tell when there’s enough thyroid hormone, so it keeps making too much TSH.

Contradicting (0)

0

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No contradicting evidence found

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Source Study

An Abnormality of Thyroid Hormone Receptor Expression May Explain Abnormal Thyrotropin Production in Thyrotropin-Secreting Pituitary Tumors

Score: 27

DOI: 10.1089/thy.1998.8.9

Similar Assertions

In certain pituitary tumors that overproduce TSH, the genetic instructions for thyroid hormone receptors are present and readable, but the receptors themselves are not made, suggesting a problem occurs after the genetic code is copied but before the protein is assembled.

27

0

90%

In certain benign tumors of the pituitary gland that overproduce TSH, the lack of thyroid hormone receptors prevents thyroid hormone from signaling the tumor to stop releasing TSH, leading to elevated thyroid hormone levels alongside abnormally high TSH.

27

0

90%

In a laboratory cell line derived from pituitary tissue, removing the thyroid hormone receptor beta prevents T3 from suppressing the production of Tshb mRNA, while removing receptor alpha does not, indicating that receptor beta is required for T3 to reduce Tshb mRNA levels under physiological conditions.

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74%