The Claim
In obese adult women who lost weight through severe calorie restriction, lower fasting concentrations of glucagon-like peptide-1 (GLP-1) at baseline and after weight loss are associated with greater weight regain over an 18-month period.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In obese women who lost weight by eating very few calories, those with lower levels of the hormone GLP-1 before and after weight loss tend to regain more weight over 18 months.
See the scientific wording
In obese adult women who lost weight through severe calorie restriction, lower fasting levels of glucagon-like peptide-1 (GLP-1) at baseline and after weight loss are associated with greater weight regain over 18 months, suggesting that GLP-1 dynamics may influence long-term weight maintenance in this population.
After weight loss, the gut produces less GLP-1, which reduces signals to the brain that tell the body it is full. This causes the person to eat more without feeling satisfied, and the body also burns fewer calories at rest. The combination of increased eating and reduced energy use leads to fat storage and weight regain.
What the research says
1 studyIn women who lost weight by eating very little, those with naturally lower levels of the hormone GLP-1 before and after losing weight tended to gain more weight back over the next year and a half. This suggests GLP-1 might help people keep the weight off.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.