Higher consumption of omega-3 fatty acids from food leads to lower levels of prostaglandin E2 in humans.

Omega 3 supplementation reduces C-reactive protein, prostaglandin E2 and the granulocyte/lymphocyte ratio in heavy smokers: An open-label randomized crossover trial

·Randomized Controlled Trial·Human·2022

Taking high doses of omega-3 fatty acids (like fish oil) for six months lowered a harmful inflammation chemical called PGE2 in people’s blood. This means eating more omega-3s can help reduce this inflammation marker.

Higher baseline expression of the PTGS2 gene and greater decreases in total colonic fatty acid content predict greater decreases in colonic prostaglandin-E2 concentrations after dietary supplementation with ω-3 fatty acids

·Cohort Study·Human·2018

When people ate more omega-3 fatty acids, their body made less of a chemical called PGE2 that causes inflammation — especially in the colon. This happened even if we couldn't predict exactly who would see the biggest drop.

Influence of Eicosapentaenoic Acid, an Omega-3 Fatty Acid, on Ultraviolet-B Generation of Prostaglandin-E2 and Proinflammatory Cytokines Interleukin-1β, Tumor Necrosis Factor–α, Interleukin-6 and Interleukin-8 in Human Skin In Vivo¶

·Cross-Sectional Study

This study showed that applying a type of omega-3 fatty acid (EPA) to sunburned skin lowered a harmful inflammation chemical called PGE2. This means omega-3s can reduce PGE2 in the body, which supports the idea that eating more omega-3s might do the same.

Low dose supplementation with two different marine oils does not reduce pro-inflammatory eicosanoids and cytokines in vivo

·Randomized Controlled Trial·Human·2006

Even though people took omega-3 supplements and their bodies absorbed more of it, their inflammation marker (PGE2) didn't go down. So, the study says eating more omega-3s didn't lower this specific inflammation chemical.