mechanistic
Analysis v1
Strong Support
Some people have a genetic variation that makes it hard for their body to turn the kind of folic acid in vitamins and fortified foods into the active form their body actually needs, which can leave them with not enough usable folate.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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People with a certain gene variant can't turn regular folic acid (in supplements) into the form their body can use, so it builds up unused and can cause problems — the study confirms this and suggests using a different type of folate instead.
Contradicting (0)
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Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.