The Claim

In healthy adult humans, insulin does not enhance vasodilation induced by sodium nitroprusside, an endothelium-independent nitric oxide donor, suggesting that insulin's vascular effects are not mediated by increasing the sensitivity of vascular smooth muscle to nitric oxide.

Source: Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
38score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

In healthy adults, insulin doesn't make blood vessels relax more when nitric oxide is already at work — meaning insulin probably doesn't improve blood flow by boosting the muscle's response to nitric oxide.

See the scientific wording

In healthy adult humans, insulin does not enhance vasodilation caused by sodium nitroprusside, an endothelium-independent nitric oxide donor, indicating that insulin’s vascular effects are not mediated by increased sensitivity of vascular smooth muscle to nitric oxide.

What the research says

1 study

  1. Study: Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

    The study shows insulin helps blood vessels relax by releasing more natural nitric oxide from the lining of blood vessels, but it doesn’t make the muscles in the vessel walls more sensitive to nitric oxide. That matches the claim.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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