The Claim
Insulin increases the activity of Na+/K+-ATPase in skeletal muscle cells, which strengthens the transmembrane sodium gradient and subsequently enhances the driving force for sodium-dependent creatine uptake mediated by the SLC6A8 transporter.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Insulin helps muscles pull in more creatine by boosting a cellular pump that creates the right conditions for creatine to get inside.
See the scientific wording
Insulin enhances Na+/K+-ATPase activity in skeletal muscle, strengthening the transmembrane sodium gradient, thereby increasing the driving force for sodium-dependent creatine transport via SLC6A8.
What the research says
3 studiesStudy: Effect of insulin upon membrane‐bound (Na+ + K+)‐ATPase extracted from frog skeletal muscle.
Insulin boosts a molecular pump in muscle cells that helps move sodium and potassium. This study shows that insulin makes this pump work harder, which supports the idea that it could help bring more creatine into cells.
The study shows insulin makes the sodium-potassium pump work harder in human muscle cells, which supports the idea that it could help pull in more creatine using sodium as a helper.
Study: Regulatory effect of insulin on the structure, function and metabolism of Na+/K+-ATPase (Review)
The study shows insulin boosts a cellular pump that helps control sodium and potassium, which supports the idea that it could help cells take in more creatine using that pump.
Related videos
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 3 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.