The Claim
Insulin significantly reduces skeletal muscle protein breakdown by an average of 15.46 nmol (100 ml leg vol.)⁻¹ min⁻¹ in healthy humans under controlled experimental conditions, independent of amino acid availability, indicating its primary anabolic role is anti-catabolic rather than stimulatory of synthesis.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In healthy humans, insulin directly lowers the rate of muscle protein breakdown by 15.46 nmol per 100 ml of leg volume per minute, regardless of amino acid levels, showing its main effect on muscle is to prevent breakdown rather than to build new protein.
See the scientific wording
Insulin significantly reduces skeletal muscle protein breakdown by an average of 15.46 nmol (100 ml leg vol.)⁻¹ min⁻¹ in healthy humans under controlled experimental conditions, independent of amino acid availability, indicating its primary anabolic role is anti-catabolic rather than stimulatory of synthesis.
Insulin binds to muscle cells and turns on a signaling chain that shuts down the cellular machinery responsible for breaking down proteins. This stops muscle proteins from being destroyed, even when no extra amino acids are present.
What the research says
1 studyInsulin doesn't make muscles grow bigger on its own, but it does stop them from breaking down — and this study proves it, even when protein levels in the blood stay the same.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.