Insulin resistance and chronic inflammation interact in a cycle that increases fat buildup in the liver.
Strongly supported
Multiple high-quality studies back this claim.
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Insulin resistance and chronic inflammation interact in a cycle that increases fat buildup in the liver.
See the technical phrasing
Insulin resistance and chronic inflammation engage in a bidirectional feedback loop that directly drives the accumulation of fat in the liver.
Excess fat in the body triggers immune cells called iNKT cells to become active, which causes the liver to become inflamed and less responsive to insulin. This inflammation and insulin resistance force the liver to store more fat, and the extra fat in the liver keeps the immune cells active, creating a cycle that worsens over time.
What the research says
Supports
6 studies
Study: Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss
This study provides evidence supporting the claim.
Contradicts
0 studies
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 6 supporting studies