When cells become resistant to insulin, fat breakdown decreases, leading to less fatty acid release into the blood and more fat accumulation in the liver.
Likely contradicted
Evidence leans against this claim.
Not medical advice. For informational purposes only. Always consult a healthcare professional.
When cells become resistant to insulin, fat breakdown decreases, leading to less fatty acid release into the blood and more fat accumulation in the liver.
See the technical phrasing
Insulin resistance suppresses lipolysis, resulting in reduced mobilization of fatty acids and increased hepatic triglyceride storage.
When insulin cannot properly signal in fat cells, the proteins that control fat breakdown do not respond correctly, so fat keeps breaking down even when it should stop. This releases too many fatty acids into the blood, which the liver takes up and turns into stored fat.
What the research says
Supports
1 study
Study: 1093-OR: Metabolite-Driven Reversal of Adipocyte Insulin Resistance Identified by Reliance, a Novel Live Lipolysis Screening Platform
This study provides evidence supporting the claim.
Contradicts
2 studies
Study: Adipose Tissue Resistance to the Antilipolytic Effect of Insulin and Niacin in Humans With Obesity.
This study provides evidence contradicting the claim.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 3 supporting studies