In certain human cells, how much creatine is inside the cell controls a specific gene switch, no matter how the creatine got in—meaning the cell cares about its internal supply, not where it came from.

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Evidence from Studies

Supporting (1)

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Evidence of an intracellular creatine-sensing mechanism that modulates creatine biosynthesis via AGAT expression in human HAP1 cells

Cross-Sectional Study

In Vitro

2023 Dec 16

The study shows that cells turn down a key creatine-making enzyme based on how much creatine is already inside them, no matter how the creatine got in. This matches the claim exactly.

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No contradicting evidence found

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Source Study

Evidence of an intracellular creatine-sensing mechanism that modulates creatine biosynthesis via AGAT expression in human HAP1 cells

Score: 4

DOI: 10.1038/s41598-023-49860-1

Similar Assertions

In certain human cells, the more creatine builds up inside, the less the cell makes on its own — like a built-in thermostat that senses creatine levels and turns down production when there's enough.

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84%

Creatine gets into human cells in two ways: one is like a precise lock-and-key system that works well at low levels, and the other is a more general process that kicks in when there's a lot of creatine around.

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Scientists made a tool in lab-grown cells that lights up when creatine is present, so they can quickly test how well different drugs or substances affect creatine levels inside cells.

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74%