The Claim
L-citrulline supplementation at 100 mg/kg/day for 10 days in healthy adults has no ergogenic effect, but this finding does not preclude ergogenic effects at higher doses, longer durations, or in different exercise modalities such as prolonged time trials or resistance training.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Taking 100 mg of L-citrulline per kilogram of body weight for 10 days does not improve athletic performance in healthy adults, but this does not mean higher doses, longer use, or different types of exercise might not have an effect.
See the scientific wording
The lack of ergogenic effect observed with 10-day L-citrulline supplementation at 100 mg/kg/day in healthy adults does not rule out potential benefits at higher doses, longer durations, or in different exercise modalities such as prolonged time trials or resistance training.
L-citrulline is converted into arginine in the kidneys, which the blood vessels use to make nitric oxide. Nitric oxide relaxes blood vessel walls, allowing more blood to flow to muscles during exercise. This increased blood flow delivers more oxygen and nutrients, which can delay muscle fatigue.
What the research says
1 studyThis study found that L-citrulline didn’t help people run longer in one specific test, but the researchers themselves said that doesn’t mean it won’t help in other situations — like longer races or for women. So the study actually supports the idea that more testing is needed in different cases.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.