The Claim
At baseline, there is no significant association between serum 25-hydroxyvitamin D concentration and skeletal muscle vitamin D receptor mRNA expression in older adults, indicating that circulating vitamin D levels do not directly correlate with VDR gene expression in muscle tissue in a cross-sectional analysis.
What the research says
Challenges is higher
Challenge is ahead, but a single strong supporting study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In older people, having more or less vitamin D in the blood doesn’t seem to change how much of the vitamin D receptor gene is active in their muscles — the two just don’t go up or down together.
See the scientific wording
In older adults, there is no significant association between serum 25-hydroxyvitamin D concentration and skeletal muscle vitamin D receptor mRNA expression at baseline, suggesting that circulating vitamin D levels do not directly correlate with VDR gene expression in muscle tissue in a cross-sectional analysis.
What the research says
1 studyThe study found that older adults with higher vitamin D levels in their blood also had more vitamin D receptors in their muscles — even before taking supplements — which is the opposite of what the claim says.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.