The Claim

L-citrulline supplementation does not produce a statistically significant change in lean mass gain in individuals undergoing resistance training.

Source: 5 Fitness Myths Science Officially Debunked in 2026

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
39score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Quantitative
1 study reviewed
In plain English

Taking L-citrulline supplements does not lead to an increase in muscle mass in people who do resistance training.

See the scientific wording

L-citrulline supplementation has no significant effect on lean mass gain in individuals undergoing resistance training.

Why this might work

Taking L-citrulline does not increase the rate at which muscle cells build new proteins or activate cells that help muscles grow bigger, so muscles do not get larger from resistance training when L-citrulline is added.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: Synergistic Effect of Long-Term L-Citruline Supplementation Combined with Exercise on Body Composition in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    This study found that taking citrulline pills along with working out didn't help people gain more muscle than just working out alone. So, citrulline doesn't seem to boost muscle growth.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.