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Strong Opposition
mechanistic
Analysis v3
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In certain human ovarian tumor cells, a type of fat called linoleic acid sticks to estrogen receptors and seems to turn them on, which might lead to harmful effects like less cell death and more...

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Evidence from Studies

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Contradicting (1)

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Linoleic acid induces human ovarian granulosa cell inflammation and apoptosis through the ER-FOXO1-ROS-NFκB pathway

Cross-Sectional Study
In Vitro
2024 Mar 16

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Source Study

Linoleic acid induces human ovarian granulosa cell inflammation and apoptosis through the ER-FOXO1-ROS-NFκB pathway

Score: 6
DOI: 10.1038/s41598-024-56970-x

Similar Assertions

When a certain type of human ovary cell is exposed to a specific amount of linoleic acid, it starts to die off more — and this might explain why high levels of this fat could mess with egg development.

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Linoleic acid might make certain human ovary cells more inflamed, based on lab tests with a specific dose.

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In certain human ovarian tumor cells, a type of fat called linoleic acid turns on a protein pathway linked to inflammation and cell death, but this only happens if a chain of other molecules (ER, FOXO1, and ROS) are active first.

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In certain human ovary tumor cells, a type of fat called linoleic acid seems to cause stress inside the cells, but blocking two specific proteins (ER and FOXO1) can undo that stress.

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