The Claim
SLC2A9 transports uric acid in Xenopus laevis oocytes, demonstrating that this gene directly mediates renal urate reabsorption.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
The SLC2A9 gene encodes a protein that moves uric acid across cell membranes in frog egg cells, indicating it plays a direct role in reabsorbing urate in the human kidney.
See the scientific wording
SLC2A9 exhibits strong uric acid transport activity in Xenopus laevis oocytes, providing biological plausibility that this gene, previously known as a fructose transporter, also directly mediates renal urate reabsorption.
A protein in the kidney's filtering tubes pulls uric acid from the blood into the tube cells, so the body keeps more uric acid instead of losing it in urine. Changes in the gene that makes this protein make it work less well, so more uric acid leaves the body and less stays in the blood.
What the research says
1 studyScientists found that a protein called SLC2A9 can move uric acid in frog egg cells, and people with certain versions of this gene have more uric acid in their blood — meaning this protein likely helps the kidneys control uric acid levels.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.