The Claim
Transdermal permeation of molecules up to 10 kDa requires the simultaneous presence of both mechanical stretching from a porous micropost array and an applied electric field to induce electroosmotic flow, indicating a synergistic effect between physical deformation and electrophoretic forces.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Molecules up to 10 kDa can only pass through the skin when a porous micropost array stretches the tissue and an electric field is applied to drive electroosmotic flow, demonstrating that physical deformation and electrophoretic forces must act together.
See the scientific wording
Transdermal permeation of molecules up to 10 kDa requires the simultaneous presence of both mechanical stretching from a porous micropost array and an applied electric field to induce electroosmotic flow, indicating a synergistic effect between physical deformation and electrophoretic forces.
When the outer layer of skin is gently stretched, it creates tiny gaps between its cells. When a weak electric current is applied at the same time, it pulls fluid and molecules through those gaps. Neither stretching nor electricity alone can move large molecules through the skin, but together they open a path that lets molecules up to 10 kDa pass through without needles.
What the research says
1 studyScientists found that big drug molecules can only get through the skin when it’s gently stretched by tiny posts AND a weak electric current is used to pull the molecules through—neither trick works alone, but together they let big drugs pass through without needles.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.