In certain human ovary tumor cells, a type of fat called linoleic acid seems to cause stress inside the cells, but blocking two specific proteins (ER and FOXO1) can undo that stress.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Linoleic acid induces human ovarian granulosa cell inflammation and apoptosis through the ER-FOXO1-ROS-NFκB pathway

Cross-Sectional Study

In Vitro

2024 Mar 16

The study shows that linoleic acid causes stress and damage in human ovarian cells through a specific chain of events involving ER and FOXO1, which matches the claim.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Linoleic acid induces human ovarian granulosa cell inflammation and apoptosis through the ER-FOXO1-ROS-NFκB pathway

Score: 6

DOI: 10.1038/s41598-024-56970-x

Similar Assertions

In certain human ovarian tumor cells, a type of fat called linoleic acid turns on a protein pathway linked to inflammation and cell death, but this only happens if a chain of other molecules (ER, FOXO1, and ROS) are active first.

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80%

When a certain type of human ovary cell is exposed to a specific amount of linoleic acid, it starts to die off more — and this might explain why high levels of this fat could mess with egg development.

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74%

In certain human ovarian tumor cells, a type of fat called linoleic acid sticks to estrogen receptors and seems to turn them on, which might lead to harmful effects like less cell death and more inflammation — and when scientists blocked those receptors, those effects went away.

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6

72%

Linoleic acid might make certain human ovary cells more inflamed, based on lab tests with a specific dose.

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72%