The Claim

In isolated hepatocytes from endurance-trained female Wistar rats, norepinephrine stimulation at concentrations ranging from 0.5 to 20 nM induces significantly greater glucose production compared to hepatocytes from untrained control rats, with trained cells exhibiting a 36% increase above basal levels versus 19% in controls at maximal norepinephrine concentration and an 86% higher absolute glucose output at 20 nM norepinephrine (132.5 ± 12.4 vs 71.4 ± 6.1 nmol/mg protein), indicating enhanced sensitivity and responsiveness of trained hepatocytes to adrenergic signaling.

Source: Enhanced glucose production in norepinephrine and palmitate stimulated hepatocytes following endurance training

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
15score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

Liver cells from female rats that were trained for endurance produce way more sugar when triggered by a stress hormone, compared to liver cells from untrained rats — showing their bodies are better tuned to respond under stress.

See the scientific wording

In isolated hepatocytes from endurance-trained female Wistar rats, norepinephrine stimulation at concentrations from 0.5 to 20 nM is associated with significantly greater glucose production compared to untrained controls, with trained cells showing a 36% increase above basal levels versus 19% in controls at maximal NE, and a 86% higher absolute glucose output at 20 nM NE (132.5 ± 12.4 vs 71.4 ± 6.1 nmol/mg protein), indicating enhanced sensitivity and responsiveness of trained hepatocytes to adrenergic signaling.

What the research says

1 study

  1. Study: Enhanced glucose production in norepinephrine and palmitate stimulated hepatocytes following endurance training

    The study looked at liver cells from trained and untrained rats and found that the trained cells made much more glucose when exposed to norepinephrine, just like the claim says.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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