mechanistic
Analysis v1
Strong Support
Long-term stress might throw your immune system out of balance, turning up inflammation and turning down protection, which could lead to autoimmune problems — especially in those who are already at risk — and this has been seen in mice prone to lupus when they're stressed by the smell of predators.
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Evidence from Studies
Supporting (1)
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Chronic Stress and Autoimmunity: The Role of HPA Axis and Cortisol Dysregulation
Narrative Review
2025 Oct 14The study talks about how long-term stress can mess up your body's control systems and lead to immune problems, including autoimmune diseases like lupus. But it doesn't test the exact stress scenario or immune changes mentioned in the claim.
Contradicting (0)
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No contradicting evidence found
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