When blood flows gently through veins, it turns on certain chemical switches on an enzyme called eNOS at two specific locations (Ser1177 and Thr495), but turns off a different switch at another location (Ser633) in the cells that line umbilical veins.

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Evidence from Studies

Supporting (1)

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Modulation of low shear stress-induced eNOS multi-site phosphorylation and nitric oxide production via protein kinase and ERK1/2 signaling

Cross-Sectional Study

In Vitro

2017 Feb

The study applied low shear stress to human umbilical vein endothelial cells and found it increased eNOS phosphorylation at Ser1177 and Thr495 but decreased it at Ser633 - exactly what the claim describes.

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Source Study

Modulation of low shear stress-induced eNOS multi-site phosphorylation and nitric oxide production via protein kinase and ERK1/2 signaling

Score: 4

DOI: 10.3892/mmr.2016.6060

Similar Assertions

When blood flows slowly, it triggers a specific chain of molecular events that turns off an important enzyme that normally keeps blood vessels healthy and protected from inflammation and plaque buildup.

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