When lifting lighter weights until muscle failure, acute muscle protein synthesis is higher than when lifting heavier weights without matching the total volume of work.
Strongly contradicted
Multiple high-quality studies challenge this claim.
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When lifting lighter weights until muscle failure, acute muscle protein synthesis is higher than when lifting heavier weights without matching the total volume of work.
See the technical phrasing
Low-load resistance training to failure results in greater acute muscle protein synthesis compared to high-load resistance training when training volume is not equated.
When muscles are worked to exhaustion with light weights, the buildup of metabolic byproducts forces more muscle fibers to fire, which triggers biochemical signals that turn on protein-making machinery in the cell, leading to increased muscle protein production.
What the research says
Supports
0 studies
Contradicts
2 studies
Study: Low-Load High Volume Resistance Exercise Stimulates Muscle Protein Synthesis More Than High-Load Low Volume Resistance Exercise in Young Men
This study provides evidence contradicting the claim.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 2 supporting studies