The Claim
In healthy young men, endogenous testosterone sufficiency is required for the normal upregulation of myogenic gene expression during resistance training, as hypogonadism attenuates the exercise-induced increases in myogenin and IGF-1 isoforms (IGF-1Ea and IGF-1Ec), thereby impairing the molecular programming necessary for muscle growth.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Young men need normal testosterone levels to get the full muscle-building benefits from weight training — low testosterone blunts the body’s muscle-growth signals.
See the scientific wording
Endogenous testosterone sufficiency is necessary for normal upregulation of myogenic gene expression during resistance training in healthy young men, as hypogonadism blunts the exercise-induced increase in myogenin (1.3-fold vs 2.7-fold, P = 0.002) and IGF-1 isoforms (IGF-1Ea: 1.9-fold vs 3.3-fold, P = 0.0005; IGF-1Ec: 2.0-fold vs 4.7-fold, P = 0.0005), impairing molecular programming for muscle growth.
What the research says
1 studyThe study shows that when testosterone levels are artificially lowered, men don’t get the same muscle growth signals from lifting weights, which supports the idea that normal testosterone levels are needed for muscles to respond properly to training.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.