The Claim

In male athletes, blunted hormonal responses to insulin tolerance testing—specifically low ACTH (<35 pg/mL at 30 minutes post-hypoglycemia), low cortisol (<19.1 µg/dL), and low growth hormone (<1.0 µg/L at 30 minutes post-hypoglycemia)—are associated with overtraining syndrome, suggesting that hypothalamic-pituitary axis dysregulation is a key component of the pathophysiology of overtraining syndrome.

Source: Diagnosis of Overtraining Syndrome: Results of the Endocrine and Metabolic Responses on Overtraining Syndrome Study: EROS-DIAGNOSIS

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
35score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

When male athletes are overtrained, their body’s stress and growth hormone responses to low blood sugar don’t react as strongly—this could mean their brain’s hormone control center isn’t working right.

See the scientific wording

In male athletes, blunted hormonal responses to insulin tolerance testing—including low ACTH (<35 pg/mL 30 min post-hypoglycemia), low cortisol (<19.1 µg/dL), and low GH (<1.0 µg/L 30 min post-hypoglycemia)—are associated with overtraining syndrome, indicating hypothalamic-pituitary axis dysregulation as a key feature of OTS pathophysiology.

What the research says

1 study

  1. Study: Diagnosis of Overtraining Syndrome: Results of the Endocrine and Metabolic Responses on Overtraining Syndrome Study: EROS-DIAGNOSIS

    The study found that athletes with overtraining syndrome had unusually low hormone responses during a stress test, which helps diagnose the condition—supporting the idea that their hormone system isn't reacting normally.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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