Taking melatonin supplements may help the heart pump better and prevent damage in people with heart failure. It works by slowing down scar tissue buildup, protecting heart cells from dying, and helping the heart regulate blood pressure and energy use more efficiently. This could lead to stronger heart contractions and less muscle wasting.

Taking melatonin supplements appears to help heart failure patients feel better and lower stress markers in their heart, but it doesn't reliably improve the heart's pumping strength.

Taking 10 mg of melatonin every night for six months can help people with a specific type of heart condition feel better and have fewer heart failure flare-ups. This improvement comes from better daily well-being and fewer hospital visits, rather than from preventing death.

Taking melatonin supplements may lower your blood pressure, blood sugar, and bad cholesterol, while also reducing inflammation and boosting your body's natural antioxidants.

Melatonin helps protect your heart and blood vessels from damage by calming inflammation and fighting off harmful molecules. It works by turning on your body's natural defense systems and protecting the energy centers inside your heart cells.

Taking melatonin by mouth might lower a specific stress marker in the blood for people with a common type of heart failure. This suggests the supplement could help take the strain off the heart and calm stress hormones, even if it doesn't change how well the heart pumps.