For men with low testosterone, taking testosterone therapy may lower their 'good' cholesterol by about 11% after a year, even though it helps other heart and metabolism factors get better.

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Pro

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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SAT-150 Trends in Blood-Based Cardiometabolic Profiles During Testosterone Replacement Therapy: A Longitudinal Study of Over 4,000 Men

Cohort Study

Human

The study found that when men with low testosterone get treatment, their 'good' cholesterol (HDL) goes down by about 11%, but other heart health markers like triglycerides get much better—which is exactly what the claim says.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

SAT-150 Trends in Blood-Based Cardiometabolic Profiles During Testosterone Replacement Therapy: A Longitudinal Study of Over 4,000 Men

Score: 55

DOI: 10.1210/jendso/bvaf149.2001

Similar Assertions

For men with low testosterone, taking testosterone therapy may lower their overall cholesterol by about 7% after a year, but it doesn’t seem to change the 'bad' LDL cholesterol.

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For men with low testosterone, giving them testosterone therapy may lower their triglyceride-to-HDL ratio by almost 20% in a year — and if their ratio was already really high (above 6), it can drop by more than two-thirds, which is good because high ratios are tied to heart and metabolic problems.

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Taking testosterone therapy might slightly lower the 'good' cholesterol and could raise the 'bad' cholesterol, which could change how your body handles fats in the blood.

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For men with low testosterone, taking testosterone therapy may slightly raise the good cholesterol (HDL) without hurting blood pressure or blood sugar levels, based on a big study called TRAVERSE.

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Giving testosterone to men with low levels might help their cholesterol and fats in the blood get better, but we still don’t know if that actually makes their heart safer or not.

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