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Strong Support

In mice, turning off one of two specific liver genes doesn’t hurt their stamina or blood sugar control after exercise, because their bodies can use backup systems to keep making glucose.

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Pro
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Evidence from Studies

Supporting (1)

10

Community contributions welcome

10

Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice

Cross-Sectional Study
Animal

The study found that mice could still exercise normally and maintain blood sugar after losing one of two key liver proteins, because the body used backup systems—just like the claim says.

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice

Score: 10
DOI: 10.1101/2023.08.22.554345

Similar Assertions

When two specific genes are turned off in the livers of mice, their bodies make less blood sugar—both when resting and exercising—because the liver can't use certain fuel sources as well. This shows those genes are important for keeping blood sugar levels up when the body needs more energy.

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88%

When mice are genetically changed so their liver can't take in two key energy-related molecules at the same time, they get tired faster during exercise — but only when both are blocked, not just one.

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87%

In mice, when two specific liver genes are turned off, their liver cells don't process energy as well—even during exercise—because they can't get enough fuel, not because they're missing the tools to do the job.

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86%

Mice that had two specific liver genes turned off couldn't keep their blood sugar stable after exercise, and their sugar levels dropped a lot compared to normal mice.

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85%