The Claim
Constitutive inactivation of the myostatin gene in 6-month-old male and female mice is associated with increased absolute maximal isometric force and absolute maximal power in the tibialis anterior muscle compared to wild-type mice, but is also associated with reduced specific maximal force and specific maximal power per unit of muscle mass.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Mice with a permanently deactivated myostatin gene have larger tibialis anterior muscles that generate more total force and power, but less force and power per gram of muscle tissue compared to normal mice.
See the scientific wording
Constitutive inactivation of the myostatin gene in 6-month-old male and female mice is associated with increased absolute maximal isometric force and absolute maximal power in the tibialis anterior muscle compared to wild-type mice, but this is accompanied by reduced specific maximal force and specific maximal power per unit of muscle mass, indicating a trade-off between muscle size and muscle quality.
When the myostatin gene is turned off, muscles grow much larger because more muscle cells form and existing ones get bigger. But the muscle doesn't add enough of the proteins that make it contract strongly, so each gram of muscle produces less force. This makes the muscle stronger overall because it's bigger, but weaker for its size.
What the research says
1 studyMice born without the myostatin gene grow bigger muscles that can push harder overall, but those muscles aren’t as strong for their size — like having a bigger engine that’s less fuel-efficient.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.