mechanistic
Analysis v1
Strong Support
When mice have a broken insulin signal in their blood vessel lining, their muscles don’t get enough sugar—even if the muscle cells themselves work fine—because the blood flow to the muscles drops.
2
0
Evidence from Studies
Supporting (1)
2
Community contributions welcome
2
Muscle microvascular blood flow responses in insulin resistance and ageing
Narrative Review
Animal
2016 Apr 15The study doesn’t look at the exact same genetically modified mice, but it shows that when blood flow in tiny vessels is impaired, muscles don’t take up glucose well, which supports the main idea in the claim.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.