Deleting a specific gene in middle-aged mice helps keep their immune system stronger as they age, kind of like how eating less does — so blocking that gene’s protein might help slow immune aging.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Caloric restriction in humans reveals immunometabolic regulators of health span

Cohort Study

Human

2022 Feb 11

The study found that turning off the Pla2g7 gene in mice led to healthier thymus glands and less inflammation as they aged, which is exactly what the claim says. It also showed that cutting calories had similar effects, and reduced Pla2g7 levels in humans.

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No contradicting evidence found

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Source Study

Caloric restriction in humans reveals immunometabolic regulators of health span

Score: 37

DOI: 10.1126/science.abg7292

Similar Assertions

If healthy middle-aged people eat 14% less food for two years, a certain gene in their fat tissue becomes less active, and this change is linked to better energy use, less body-wide inflammation, and healthier metabolism — meaning this gene might help the body adapt to eating less.

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